Proven Additional Benefits: Reduces the risk of major adverse cardiovascular events (such as cardiovascular death and non-fatal myocardial infarction) in patients with type 2 diabetes; reduces weight, lowers blood pressure, and reduces diabetic complications.
Potential New Uses
1. Alzheimer's Disease: Studies in 3xTg AD mice have shown that it can improve learning and memory and reduce Aβ plaques and neurofibrillary tangles through the GLP-1R/SIRT1/GLUT4 pathway.
2. MASH: Multiple phase 3 clinical trials are underway to determine the efficacy of Smegglutide in MASH.