It is not recommended to use Smegglutide injection after opening and refrigerating it for three months:

1. Risk of drug inactivation: The shelf life after opening is 5-6 weeks. Three months of refrigeration far exceeds the shelf life, and the drug's effectiveness is essentially lost.

2. Safety hazards: Using expired drugs may cause discomfort due to spoilage.

3. Storage recommendations: Unopened, it should be refrigerated at 2-8℃. After opening, it should be used strictly according to the specified time.