GLP-1 Receptor Agonists: These include prescription medications such as semaglutide and liraglutide, which are typically administered via injection or orally. Clinical trials have demonstrated that they can help overweight or obese individuals achieve significant weight loss (e.g., an average reduction of 10–15%); however, they are primarily prescribed for the treatment of diabetes or specific forms of obesity.

Endorphins: Polypeptides naturally secreted by the body during physical exercise. They help suppress appetite, enhance exercise endurance, and improve mood - thereby indirectly supporting weight loss - though their release requires the stimulus of regular physical activity.

Other Bioactive Peptides: Examples include whey peptides and soy peptides. These may aid in weight loss by modulating gut microbiota and metabolic processes; however, their efficacy varies from person to person and is generally less pronounced than that of pharmaceutical interventions.