Adults who are obese or overweight and have difficulty achieving their desired weight loss through diet and exercise. This adult population includes both genders; the overall weight loss mechanism is similar for men and women using semaglutide oral tablets, but there may be some subtle differences in individual responses. For individuals with weight loss needs and who meet the indications for medication use, semaglutide oral tablets can be a treatment option, but should be used under the evaluation and guidance of a physician.