According to FDA reports, the most common side effects of semaglutide include nausea, diarrhea, vomiting, constipation, abdominal pain, bloating, dizziness, headache, indigestion, hypoglycemia, gastroenteritis, and gastroesophageal reflux disease.

In more serious cases, semaglutide may cause pancreatitis, gallstones, acute kidney injury, retinal damage, and increased heart rate.

People taking semaglutide have a 4.6 times higher incidence of pancreatitis than those taking other types of weight-loss drugs, and it is also associated with an increased incidence of gastroparesis.