1. Different ingredients: Telpolide is a dual agonist of glucagon-like peptide-receptor and glucose-dependent insulinotropic polypeptide. During treatment, it promotes insulin secretion, thus controlling blood sugar.

2. Different pharmacological effects: Telpolide primarily controls insulin secretion and is effective in treating insulin-dependent diabetes. Smegglutide injection promotes glucose metabolism and inhibits glucose absorption, thereby treating diabetes.

3. Different therapeutic range: Telpolide is mainly used for the treatment of insulin-dependent diabetes. Smegglutide injection can be used for the treatment of type 2 diabetes that is poorly controlled by diet and exercise.

4. Different costs: Telpolide is more expensive than smegglutide injection.

5. Different side effects: Telpolide is more likely to cause adverse side effects such as fatigue and nausea.